Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

نویسندگان

  • Reinhold Zimmer
  • Elmar Schmidt
  • Michal Andrä
  • Marcel-Antoine Duhs
  • Igor Linder
  • Hans-Ulrich Reissig
چکیده

A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2009